Prazosin for military combat-related PTSD nightmares: A critical review.
January 22, 2015
Writer BW, Meyer EG, Schillerstrom JE.
The Journal of Neuropsychiatry and Clinical Neurosciences, Vol 26(1), Win 2014. pp.24-33. Publisher: American Psychiatric Assn [Journal Article]
Abstract: Military combat is a common trauma experience associated with posttraumatic stress disorder (PTSD). Trauma-related nightmares are a hallmark symptom of PTSD. They can be resistant to label-pharmacological PTSD treatment, and they are associated with a variety of adverse health outcomes. The purpose of this article is to review and evaluate prazosin therapy for combat-related PTSD nightmares. Consistent with available literature for all-causes PTSD nightmares, prazosin is an effective off-label option for combat-related PTSD nightmares. Future trials may further instruct use in specific combat-exposure profiles.